R & D Support

Collagen is the principal composition of human tissue and the predominant biomolecule found in blood vessels, dermis, tendons, ligaments, cartilage, and the organic phase of bone. Collagen contains 21 kinds of amino acids, mainly including glycine, proline and hydroxyproline. The amino acids can be embed in three polypeptide chains to form a triple helix structure, and then the  collagen fibers formate.

The intact triple helix structure.(molecular weight is about 300,000 daltons)

SDS-PAGE shows different class of collagen. (A)BIOT collagen with intact triple helix structure; (B)Common collagen from the other manufactures without triple helix and contains much smaller molecule; (C)Gelatin without triple helix structure. The picture shows that the true collagen is with intact triple helix structure and biological activity, but gelatin and other hydrolyed collagen is denatured protein without biological activity and molecular weight distribute irregular.